The effect of oral antidiabetic agents on A1C levels: a systematic review and meta-analysis, published in Diabetes Care concludes:
The benefit of initiating an OAD agent is most apparent within the first 4 to 6 months, with A1C levels unlikely to fall more than 1.5% on average. Pretreated A1C levels have a modest effect on the fall of A1C levels in response to treatment.
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