Is there any evidence that in patients with asthma, seasonal flu vaccine can trigger an acute exacerbation of asthma?
The answer being:
CKS clinical guidance on seasonal influenza vaccinations (1) has a section on its use in people with asthma. This states:
“No increase in asthma-related adverse effects was reported with vaccination.”
Specifically they discuss harms of inactivated vaccines and note:
“Six studies were identified. No statistical difference was found, compared with placebo, in asthma exacerbations in the 2 weeks following influenza vaccination (two studies, n = 2306), lung function and increased use of bronchodilators (four studies, n = 4924), medical consultations (three studies, n = 5092), and new or increased oral corticosteroid use (two studies, n = 4419).”
A fuller discussion of the data is available in the Cochrane review (2) that examined the effectiveness of influenza vaccination in children (older than 2 years of age) and adults with stable asthma (search date: up to September 2007).
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